The fifth round of Rome Nuclear Talks Stall as U.S. and Iran Clash Over Uranium Enrichment. The nuclear talks between Tehran and Washington concluded in Rome on Friday, May 23, 2025, with no breakthrough in sight as uranium enrichment remains the central obstacle. Trump pushes for zero enrichment while Iran demands sanctions relief. Regional tensions rise amid Israeli threats. Despite growing international pressure and increasing tensions across the Middle East, the core issue of uranium enrichment continues to divide the United States and Iran, leaving the future of diplomacy uncertain.